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Cialis® (tadalafil) Reaches $1 Billion Global Sales Milestone
07.28.05 (7:23 pm)   [edit]




Cialis® (tadalafil) Reaches $1 Billion Global Sales Milestone


26 Jul 2005


Lilly ICOS LLC, marketer of tadalafil (Cialis), a PDE5 inhibitor indicated for the treatment of erectile dysfunction (ED), announced today that the drug has achieved $1 billion in global sales since launching in Europe a little more than two years ago.

In January 2005, tadalafil became the leading ED treatment in France, a lead it has held through May, based on the latest market share data . It is also performing very well in other countries, including the United Kingdom, Italy, Germany, United States, Canada, Australia, Mexico and Brazil.

"We are very pleased with the performance of Cialis and the steady development of the brand since its launch two years ago," said Rich Pilnik, President of Lilly's EMEA region. "Millions of men suffer from ED and the growth of the market demonstrates that patients are speaking to their healthcare providers about ED and seeking treatment options."

Tadalafil was the second PDE5 inhibitor drug to become available in Europe. It is currently marketed in approximately 100 countries including the United States, Australia, Brazil, Mexico, Canada and across Europe and Asia.

"Passing the $1 billion mark is an important milestone for Lilly ICOS and a great accomplishment for the Cialis team" said Paul Clark, Chairman and Chief Executive Officer of ICOS Corporation. "Since 2003, men with erectile dysfunction have had a choice of oral treatments for their condition - a condition which may impact on relationships and daily life."

About ED

ED is defined as the consistent inability to attain and maintain an erection sufficient for sexual intercourse. ED affects an estimated 189 million men worldwide . Experts believe that 80 percent to 90 percent of ED cases are related to a physical or medical condition, such as , cardiovascular diseases, and treatment, while 10 percent to 20 percent are due to psychological causes . In many cases, however, both psychological and physical factors contribute to the condition.

About Lilly ICOS LLC

Lilly ICOS LLC, a joint venture between ICOS Corporation and Eli Lilly and Company, developed Cialis for the treatment of erectile dysfunction. ICOS Corporation, a biotechnology company headquartered in Bothell, Washington, is dedicated to bringing innovative therapeutics to patients. ICOS is working to develop treatments for serious unmet medical conditions such as benign prostatic hyperplasia, pulmonary arterial hypertension, cancer and inflammatory diseases. Additional information about ICOS is available at
http://www.ICOS.com" title="http://www.ICOS.com" target="_blank"http://www.ICOS.com.

Lilly, a leading innovation-driven corporation is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers - through medicines and information - for some of the world's most urgent medical needs.

Except for historical information contained herein, this press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are based on current expectations, estimates and projections about the industry, management beliefs and certain assumptions made by the management of ICOS and Lilly. Investors are cautioned that matters subject to forward-looking statements involve risks and uncertainties, including economic, competitive, governmental, technological, legal and other factors discussed in the two companies' respective filings with the Securities and Exchange Commission, which may affect the business and prospects of the two companies and Lilly ICOS. Results and the timing and outcome of events may differ materially from those expressed or implied by the forward-looking statements in this press release. More specifically, there can be no assurance that Cialis will achieve commercial success or that competing products will not pre-empt market opportunities that might exist for the product.

Jane Calloway, (Lilly), +1-317-651-5870
Lacy Fitzpatrick, (ICOS), +1-425-415-2207

lillymedia.com

Source:MedicalNewsToday

 
Diabetes,Impotence, and Viagra
07.25.05 (2:12 am)   [edit]

Diabetes,Impotence, and Viagra


Approximately 8.7 million, or 8.7% of all men over the age of 20 in the United States have diabetes.The most life-threatening consequences of diabetes are heart disease and stroke, which strike people with diabetes more than twice as often as they do others. Other complications of diabetes include blindness,impotence, kidney disease, and amputations.
Millions of men suffer from impotence, and it is more common among men with diabetes than others. While it is estimated that 15-25% of men experience erectile dysfunction by the age of 65, it has been reported to affect 50-60% of men with diabetes over the age of 50.


How Diabetes related to Impotence
The most common cause of impotence in men with diabetes is damage to his nervous system.Nerves carry messages back and forth between the brain and other parts of the body. All of your nerves together make up the nervous system.Some nerves tell the brain what is happening in the body. For example, when you step on a tack, the nerve in your foot tells the brain about the pain.Other nerves tell the body what to do. For example, nerves from the brain tell your stomach when it is time to move food into your intestines.
nervous system


The nervous system has four main parts—cranial, central, peripheral, and autonomic. All these nerves goes to different organs of your body.Out of these Autonomic nerves go from your spinal cord to your lungs, heart, stomach, intestines, bladder, and sex organs.


Diabetes can damage the peripheral, autonomic, and cranial nerves.
Having high blood glucose for many years can damage the blood vessels that bring oxygen to some nerves. High blood glucose can also hurt the covering on the nerves. Damaged nerves may stop sending messages. Or they may send messages too slowly or at the wrong times.


Diabetic neuropathy (ne-ROP-uh-thee) is the medical term for damage to the nervous system from diabetes.


As Autonomic nerves go to the penis, Damage to these nerves can prevent a man’s penis from getting firm when he wants to have sex. This condition is called erectile dysfunction or impotence (IM-po-tents). Many men who have had diabetes for many years experience it.


viagra and impotence
generic viagra
Viagra has been tested and found effective in men with diabetes. Viagra works by helping to relax the smooth muscles in the penis during sexual stimulation, allowing increased blood flow. In an early study involving 21 patients, use of Viagra improved the quality of erections in 48% receiving the 25 mg dose and 52% of those receiving 50 mg. A larger study of 268 men with diabetes found improved erections in 56% of those receiving Viagra. These results compare to ranges of 65% to 88% percent improvement reported by men without diabetes.


Apart from viagra you can directly control impotence by preventing nerve damage,here it is how
Keep your blood glucose as close to normal as you can.
Limit the amount of alcohol you drink.
Don’t smoke.
Tell your doctor if you have problems when you have sex.


For More information


To find a diabetes teacher near you, call the American Association of Diabetes Educators toll-free at 1–800–TEAMUP4 (1–800–832–6874), or look on the Internet at www.diabeteseducator.org and click on “Find a Diabetes Educator.”


About the author


robert stalling is a webmaster of online pharmacy of generic drugs for sexual health,weight loss,and hair loss.

 
Change your lifestyle to reduce impotence
07.07.05 (12:43 am)   [edit]

Change your lifestyle to reduce impotence:
According to many clinical studies changing your life style can help you to reduce your impotence


Problem.Such important life style changes are quit smoking,control diabetes,avoid alcohol,Stop illicit drug use,Exercise,Reduce Stress and anxiety,Stop fear of failure etc. 


Quit smoking:


 Smoking increases the risk of erectile dysfunction by around 50% for men in their 30s and 40sDuring an erection, large quantities of blood flow, under pressure, into the penile arteries.This causes the veins which drain the penis to become compressed, so preventing the immediate outflow of blood. This process is significantly impaired by smoking.=http://bigwhiteguy.com/archiv...;h=400&w=312&sz=3 9&tbnid=2QUyoZ1MdTAJ: &tbnh=120&tbnw=93 &hl=en&start=31&a mp;prev=/images%3Fq%3D%2B smoking%26start%3D20%26sv num%3D10%26hl%3Den%26lr%3 D%26rls%3DGGLD,GGLD:2005- 12,GGLD:en%26sa%3DN"
The Massachusetts Male Aging Study (MMAS) found that smoking worsens cardiovascular problems that lead to impotence.Quitting smoking can help some men partly or fully restore erectile function. The MMAS results underscored this point, especially in men under 60.


Control diabetes:


 Diabetes, for example, may contribute to as many as 40% of impotence cases. Between one-third and one-half of all diabetic men report some form of sexual difficulty. Blocked arteries and nerve damage are both common complications of diabetes; when the blood vessels or nerves of the penis are involved, erectile dysfunction can result. In June 2004, researchers reported on the first study looking at men with type 2 diabetes and symptomless heart disease. Their report in Circulation: Journal of the American Heart Association suggests that erectile dysfunction (ED) in men with type 2 diabetes may signal silent coronary artery disease (CAD). The study found that those who had silent CAD and type 2 diabetes were nine times more likely to have ED than diabetic men who did not have silent heart disease.
Take control of your diabetes. Good blood glucose control can prevent the complications that lead to impotence.


Avoid alcohol:


Excessive alcohol consumption disrupts hormone levels and can lead to nerve damage. This type of impotence may be reversible or permanent depending on the severity of the nerve damage. Some clinical studies suggest about 25 percent of all alcoholics become impotent--even after they stop drinking.


Stop illicit drug use:


=http://www.defence.gov.au/new...;h=845&w=600&sz=3 95&tbnid=dNaGCn60Lv8J :&tbnh=144&tbnw=1 02&hl=en&start=5& amp;prev=/images%3Fq%3Dil licit%2Bdrug%2B%26svnum%3 D10%26hl%3Den%26lr%3D%26r ls%3DGGLD,GGLD:2005-12,GG LD:en%26sa%3DN" Illicit drugs such as marijuana, cocaine, heroin, barbiturates, and amphetamines act on the central nervous system, impairing the body's ability to respond sexually.


Exercise:


=http://sln.fi.edu/biosci/heal...;h=282&w=307&sz=2 5&tbnid=MzIiSfCpUnMJ: &tbnh=102&tbnw=11 2&hl=en&start=4&a mp;prev=/images%3Fq%3Dexe rcise%26svnum%3D10%26hl%3 Den%26lr%3D%26rls%3DGGLD, GGLD:2005-12,GGLD:en"
NEW YORK (Reuters Health) - Showing that what's good for your heart is good for your sex life, researchers have found that regular, moderate exercise may prevent impotence.


Reduce Stress and anxiety:


=http://askmen.com/sports/heal...;h=225&w=150&sz=7 &tbnid=Fk7OYyl9lroJ:& amp;tbnh=102&tbnw=68& amp;hl=en&start=40&am p;prev=/images%3Fq%3DStre ss%2B%26start%3D20%26svnu m%3D10%26hl%3Den%26lr%3D% 26rls%3DGGLD,GGLD:2005-12 ,GGLD:en%26sa%3DN"When you're stressed and focusing on other issues apart from sex, you might find that you don't want to have sex as often and there might be a drop in your ability to perform when you do try.Reducing stress can mean better erections when you want them.


Stop fear of failure:


=http://www.cartoonmotivators....;h=340&w=340&sz=2 8&tbnid=EFm0oMzCRaoJ: &tbnh=115&tbnw=11 5&hl=en&start=2&a mp;prev=/images%3Fq%3Dfea r%2Bof%2Bfailure%26svnum% 3D10%26hl%3Den%26lr%3D%26 rls%3DGGLD,GGLD:2005-12,G GLD:en%26sa%3DN"Anxiety about your sexual prowess (commonly called performance anxiety) can, in itself, contribute to failure. By putting pressure on yourself, you become too anxious to get an adequate erection.



Along with lifestyle changes use treatments such as  viagra and other drugs,penile implants, vacuum erection devices, injection therapy, and urethral suppositories etc.
For more detail information about these treatments click solutions to your impotence problem.

 
solutions to your impotence problem
07.02.05 (12:49 am)   [edit]

Solutions to your impotence problem



Before i tell you the ways to solve your impotence problem it is worth to provide the vary basic reason behind the impotence and here it is:
"Impotence" is nothing but a condition in which a men cannot achieve or maintain a firm erection.
There are no muscle contractions involved in making the penis erect,To become erect, the penis instead uses pressurized blood.The penis can be either limp or erect, depending on the flow of blood.


for more information about how erection occurs see The Technology of Erection.
When a man becomes aroused, the arteries leading into the penis open up so that pressurized blood can enter the penis quickly. The veins leaving the penis constrict. Pressurized blood is trapped in the corpus cavernosa, and this blood causes the penis to elongate and stiffen. The penis is erect.
If the arteries leading to the penis do not open up properly, it is difficult or impossible for a man to become erect. This problem is the leading cause of impotence(erectile dysfunction).


To solve an erection problem when the cause is poor blood flow, you need to open the arteries.


Both physical and psychlogical factors are responsible for impotnce in men.All Physical Causes of Impotence reduces or prevents the blood flow to the penis.
whereas a men with Psychological Causes of Impotnce feels anxious,guilty, or depressed. This anxiety can often make the impotence worse.
Only about 10% of impotence cases have a psychological cause.


If you have the same problem then let me tell you that Impotence can be treated and often cured.Acccording to American Medical Association is doctors can effectively treat 95% of impotence cases.


So according to the basic of erection a man must be able to move blood into the penis and maintain it there in order to achieve an erection.Arteries are the vehicles which bring the blood into the penis.Any process which damages the arteries and increases the chances of vascular disease would make a man more likely to have impotence.
so,Whatever will be the treatment for impotence,all treatment blocks any activity which reduces blood flow in the penis.


There are various ways to solve your impotence  problem which includes:
Drug Therapy:


In drug therapy various drugs such as Viagra® ,Cialis® (tadalafil),and Levitra® (vardenafil) are used.
An enzyme cGMP tells smooth muscles that line an artery to relax. When they relax, blood flow increases.
Another enzyme called phosphodiesterase (PDE) deactivates the cGMP. 
PDE5 is an enzyme that found in penis accepts cGMP and breaks it down henec reducing the flow of blood in penis.
Viagra® contains sildenafil citrate a chemial which blocks (PDE),and helps men to sustain erection for long time. 
Cialis® (tadalafil) and Levitra® (vardenafil). 
blocks PDE5 with different chemicals.
Injection therapy:


There are several drugs which can be injected directly into the erectile tissues of the penis to cause an erection. The most commonly used are papaverine (Papaverine hydrochloride), phentolamine (Regitine), and prostaglandin E1 (Caverject, Prostin, or Alpoprostadil), which can be taken singularly or in combination. Erection usually begins within 15 minutes and may last several hours.


Penile injection therapy involves injecting a single drug or a combination of drugs into the side of the penis. This produces a hard erection that can last for one to two hours.These drugs must be used exactly as prescribed by the physician. If not used correctly, the result could be a prolonged erection, called priapism. When priapism occurs, the blood fails to drain from the penis.This can damage the penile tissue and be extremely painful. A person who has a history of substance abuse, therefore, would be a risky candidate for this therapy since its success requires the exact use of the prescribed drug. Penile injections would be a difficult option for an individual with SCI with limited hand function to use on his own.He must have a partner who is willing to learn to give the injections.
Bimix and Trimix are injectables for intracavernosal administration.They refer to any combination of either two or three chemicals. Bimix is often a mixture of papaverine and phentolamine, while Trimix (PPP) would add PGE1.Other cocktails are used, mainly in Europe. These mixtures are not commercially available but must be mixed by a compounding pharmacy.They are generally much cheaper than Caverject or Edex, and tend to minimize aching in the penis or testicles which is a problem in some men with Prostaglandin (PGE-1) alone. A compounding pharmacy is one which will create custom medications on a doctor's prescription; it usually doesn't include the corner drugstore or large chain pharmacies.
Vacuum erection device:


Mechanical vacuum devices cause erection by creating a partial vacuum around the penis, which draws blood into the penis, engorging it and expanding it. The devices have three components: a plastic cylinder, in which the penis is placed; a pump, which draws air out of the cylinder; and an elastic band, which is placed around the base of the penis, to maintain the erection after the cylinder is removed and during intercourse by preventing blood from flowing back into the bod. One variation of the vacuum device involves a semirigid rubber sheath that is placed on the penis and remains there after attaining erection and during intercourse.
Surgery:


Surgery usually has one of three goals:


1.to implant a device that can cause the penis to become erect; 
2.to reconstruct arteries to increase flow of blood to the penis; 
3.to block off veins that allow blood to leak from the penile tissues 
  
  Implanted devices, known as prostheses, can restore erection in many men with impotence. Possible problems with implants include mechanical breakdown and infection. Mechanical problems have diminished in recent years because of technological advances
4>Penile implants:Penile implants (often called "internal penile pumps") are one of several erectile dysfunction treatment options. The inflatable penile prosthesis is a pump system surgically placed in the penis. It allows a man to have an erection whenever he chooses. The penis does not deflate after orgasm until the man himself pushes a release valve that is part of the prosthesis. A penile prosthesis is usually used when there is a clear medical cause for the erection problem and when erections are unlikely to improve naturally. Sometimes a penile prosthesis is implanted during surgery to reconstruct the penis when scarring has caused erections to curve. A penile prosthesis changes the body permanently and so is not commonly used to treat stress-related erection problems. 
  About 90% to 95% of inflatable prosthesis surgeries are successful; that is, the implants produce usable erections. It is not known how many men have the surgery and then are rarely sexually active, however. Satisfaction rates with an inflatable implant are high; typically 80% to 90% of men express satisfaction and say that they would choose surgery again. More detailed questions, however, suggest that some men who overall say they made the right choice still feel dissatisfied with the appearance and size of the penis or their pleasure during sex.
Urethral suppository:


MUSE is short for "medicated urethral system for erection." This treatment is based on the discovery that the urethra (the tube passing from the bladder to the tip of the penis through which urine is passed and semen ejaculated) can absorb certain medications, which can then pass into the surrounding erectile tissue creating an erection.  
The active ingredient in MUSE is alprostadil. This is identical to a naturally occurring substance within the penis which is involved in the development of an erection. Alprostadil has been used in the treatment of impotence for many years. Before the introduction of MUSE it had to be injected into the penis when an erection was wanted. Alprostadil relaxes the muscles in the erectile tissue of the penis allowing increased blood flow, the basis of a normal erection. In MUSE, alprostadil is formulated as a small pellet which is supplied in a specially designed applicator. Each MUSE applicator is individually foil wrapped. The applicator has a narrow stem which can be introduced easily into the urethra. After inserting the applicator, the alprostadil pellet is then released into the urethra by depressing a button on the top of the applicator. The manufacturer recommends that immediately prior to insertion of MUSE, the man urinates and then gently shakes the penis several times to remove excess urine. A moist u  urethra makes administration of MUSE easier and facilitates the absorption of alprostadil.


A man generally will get an erection within 10-15 minutes of application. The erection will last about 30-60 minutes. When this form of treatment is effective, an erection generally lasts 30 to 60 minutes. Extremely rarely a prolonged erection may occur. MUSE can be used twice in any 24 hour period, however 2 units should not be used consecutively Side effects have been reported only infrequently. When first using MUSE, some men experience minor discomfort from insertion but prior urination will reduce the chance of this happening. Following the first dose of MUSE, fainting has occurred, but only in an extremely small proportion of men. However, for this reason, it is recommended that the first dose of MUSE should be in the doctor's office. Other side effects that have been reported, albeit extremely rarely, include light-headedness, dizziness, fainting, rapid pulse and swelling of the leg veins. Patients are advised not to drive up to one hour after using MUSE.
 
Non-prescription treatments for impotence:


Cock ring:


A cock ring is a strap or ring that fits behind the scrotum around the base of the penis. (Some rings just fit around the base of the shaft, such as the ones that come with pumps.) It keeps blood from flowing back out of the penis, keeping it hard longer. They vary from simple rubber rings to straps that fasten with a snap or Velcro to truly complex leather systems of straps and rings that are used more for bondage than for erectile dysfunction. There is also a prescription constriction band called Actis that has a slide closure. It constricts the base of the penis, preventing blood from flowing back out of the corpora cavernosa. 
If you filled a water balloon with water until it was rigid and then just let go of it, the water would leak back out and the balloon would collapse. If you fill the balloon and then fasten a rubber band around the base, the water stays in and the balloon stays rigid. Cock rings work on the same principle as the rubber band.
Herbal treatments: Among the herbs used for erectile dysfunction are yohimbine, gingko biloba (to increase blood flow), ginseng, pygeum, and muira puama.


Penile sheath:


A penile sheath or prosthesis is a rigid or semi-rigid support put over the penis to support it for intercourse. The support is placed on top of the penis and anchored behind the scrotum with a loose rubber band. A condom is then put on over the penis and prosthesis. One popular sheath is made by Condex. Some people say they help a great deal; others complain of reduced sensation. You might see if you can try one out and decide whether you like it before you buy.


hormonal therapy for impotence:


A severe deficiency of the male hormone, testosterone, can cause impotence. The nature of the treatment is to give the man either oral testosterone or an injection in the arm or buttocks to raise the hormone to acceptable levels. In these cases, the treatment can be an effective one. Only about 4% of the male population, however, have the problem and can benefit from the treatment. Side effects of testosterone replacement therapy can be serious, and patients with a medical history that includes liver disease, heart disease, kidney problems, or prostate cancer should probably avoid supplemental testosterone. This chemical can lead to the retention of fluids, enlargement of the prostate, and damage to the liver.  
Men with low sex drive and erectile dysfunction may have low levels of testosterone (the male hormone). As a general guideline, a testosterone level of 300 ng/dL or less is considered low, but this varies depending on the laboratory that does the testing and the time of day the sample is taken. Hormone replacement may be beneficial, especially when used in combination with other therapies for erectile dysfunction; however, testosterone supplementation alone is not particularly effective in treating erectile dysfunction 
Sexual desire (libido) and an overall sense of well-being are likely to improve when serum testosterone levels (the level of the male hormone in the blood) are restored.


Replacement testosterone is available in the following forms:



Injections:


Injections are the most reliable way to restore testosterone levels, but this therapy requires periodic injections (usually every 2 weeks) to sustain an effective level. It also causes high hormone levels right after the injection and low hormone levels just before the next shot. This is thought to be slightly more risky than other methods that maintain a moderate hormone level throughout the treatment period.
Skin patches and gels: Skin patches and gels that are rubbed into the skin deliver a sustained dose and are generally well accepted. A strip that is placed in the mouth on the gums is also available. With the patches and the gels, skin rashes and irritation are the most common problems.
Oral therapy (pills):


This is the least effective therapy. Pills are also associated with a small risk of liver problems. Testosterone pills are not recommended.  


Impotence treatments all have different complications and side effects. However, the best treatment for impotence depends on many things. These include a man's health and relationship, as well as personal and physical tolerance for the treatment.


Contact a urologist who specializes in impotence treatments. The doctor will be able to diagnose your impotence and discuss various treatments with you and your spouse or partner.